The article is devoted to the problem of connection between biological substrate of obsessive-compulsive disorder and its typical psychological features. The main attention is paid to disfunction of cortico-striato-thalamo-cortical loops and basal ganglia as the reason of obsessive-compulsive symptoms. Obsessive-compulsive disorder is differentiated from anxiety disorders spectrum. Etiology of compulsive handwashing and compulsive checking is compared. Data of cognitive researches of this theme are interpreted, include response inhibition test. Assumptions about nature of obsessive thoughts “trap” are made.
According to the results of the study, despite the fact that the psychological manifestations of OCD reminds those in anxiety disorders, it’s etiology is significantly different from them. OCD forms its own group of disorders characterized by intrusive thoughts and actions. This spectrum includes dysmorphophobia, compulsive hoarding, trichotillomania, excoriation, drug-induced obsessive-compulsive disorder, and indeterminate obsessive-compulsive disorder. OCD has a clearly defined neuroanatomical substrate: orbitofrontal cortex, anterior cingulate cortex and basal ganglia, which are part of the cortico-striato-thalamo-cortical loops. The key to the development of OCD is the pathological functional connection between these structures. Symptoms of the disorder arises because of the predominance of the direct pathway of the basal ganglia over the indirect. The anterior cingulate cortex is associated with compulsive cheking, whereas areas of the prefrontal and temporal cortex and their connection with the cerebellum are associated with compulsive handwashing. Since obsessive-compulsive behavior and OCD loop mutually reinforce each other, a vicious circle is formed between psychological symptoms and neurological disorders.
. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th Edition. Washington, DC: American Psychiatric Association; 2013. 970 p. Available from: http://b-ok.org/book/2826458/0d493f.
Atmaca, M., Yildirim, H., Ozdemir, H., Tezcan, E., & Poyraz, A. K. Volumetric MRI study of key brain regions implicated in obsessive–compulsive disorder. Progress in neuro-psychopharmacology and Biological Psychiatry, 2007, 31.1: 46-52. Available from: https://www.sciencedirect.com/science/article/pii/S027858460600265X DOI: 10.1016/j.pnpbp.2006.06.008.
Chamberlain, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., & Sahakian, B. J. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neuroscience & Biobehavioral Reviews, 2005, 29.3: 399-419. Avaliable from: https://www.ncbi.nlm.nih.gov/pubmed/15820546 DOI: 10.1016/j.neubiorev.2004.11.006.
Jonathan S. Abramowitz, Dean McKay, Eric A. Storch. The Wiley Handbook of Obsessive Compulsive Disorders. Pondicherry: Wiley [Internet]. 2017. 1268 p. Available from: http://b-ok.org/book/3377418/abc444.
Maia, T. V., Cooney, R. E., & Peterson, B. S. The neural bases of obsessive–compulsive disorder in children and adults. Development and psychopathology, 2008, 20.4: 1251-1283. Avaliable from: https://www.cambridge.org/core/journals/development-and-psychopathology/article/neural-bases-of-obsessivecompulsive-disorder-in-children-and-adults/C6198A4B7C1EEB9E6483784F46896246 DOI: /10.1017/S0954579408000606.
Menzies, L., Achard, S., Chamberlain, S. R., Fineberg, N., Chen, C. H., Del Campo, N., ... & Bullmore, E. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain [Internet]. 2007; 130(12), 3223-3236 p. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17855376 DOI: 10.1093/brain/awm205.
Michael A. Jenike, Hans C. Breiter, Lee Baer. Cerebral Structural Abnormalities in Obsessive-compulsive Disorder: A Quantitative Morphometric Magnetic Resonance Imaging Study. Arch Gen Psychiatry [Internet]. 1996 Jul; 53(7):625-632 p. Available from: https://www.ncbi.nlm.nih.gov/pubmed/8660129 DOI: 10.1001/archpsyc.1996.01830070073011.
Middleton FA. Revised Neuroanatomy. Frontal-subcortical circuits in psychiatric and neurological disorders, 2001, 44. Avaliable from: https://www.cs.cmu.edu/afs/cs/academic/class/15883-f13/readings/middleton-2001.pdf.
Milad, M. R., & Rauch, S. L. Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends in cognitive sciences, 2012, 16.1: 43-51. Avaliable from: https://www.sciencedirect.com/science/article/pii/S1364661311002361. DOI: 10.1016/j.tics.2011.11.003.
Nakao, T., Okada, K., & Kanba, S. Neurobiological model of obsessive–compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry and clinical neurosciences, 2014, 68.8: 587-605. Avaliable from: https://onlinelibrary.wiley.com/doi/full/10.1111/pcn.12195 DOI: 10.1111/pcn.12195.
O'Sullivan, R. L., Rauch, S. L., Breiter, H. C., Grachev, I. D., Baer, L., Kennedy, D. N., ... & Jenike, M. A. Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biological Psychiatry [Internet]. 1996; 42(1), 39-45 p. Available from: https://www.sciencedirect.com/science/article/pii/S0006322396002971 DOI: 10.1016/S0006-3223(96)00297-1.
Rauch, S. L., Wedig, M. M., Wright, C. I., Martis, B., McMullin, K. G., Shin, L. M., ... & Wilhelm, S. Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive–compulsive disorder. Biological Psychiatry, 2007, 61.3: 330-336. Avaliable from: https://www.ncbi.nlm.nih.gov/pubmed/16497278 DOI: 10.1016/j.biopsych.2005.12.012.
Szeszko, P. R., Robinson, D., Alvir, J. M. J., Bilder, R. M., Lencz, T., Ashtari, M., ... & Bogerts, B. Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. Archives of general psychiatry [Internet]. 1999; 56(10), 913-919. Available from: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/205372 DOI: 10.1001/archpsyc.56.10.913.
Van Ameringen M, Patterson B, Simpson W. DSM-5 obsessive-compulsive and related disorders: clinical implications of new criteria. Wiley Periodicals, Inc. [Internet]. 2014 March; 31 (6): 487-493. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/da.22259 DOI: 10.1002/da.22259.
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